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KMID : 0359920130320040164
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Korean Journal of Nephrology
2013 Volume.32 No. 4 p.164 ~ p.170
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Correlation between periodontitis and chronic kidney disease in Korean adults
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Han Seung-Seok
Shin Na-Ra
Lee Su-Mi
Lee Ha-Jeong
Kim Dong-Kie
Kim Yon-Su
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Abstract
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Background: Periodontitis and chronic kidney disease (CKD) are important health issues; however, the association between periodontitis and CKD markers, especially in Korean adults, remains elusive.
Methods: Data on 15,729 Korean adults were obtained from the Korean National Health and Nutritional Examination Surveys IV and V. The CKD markers included a decreased estimated glomerular filtration rate (eGFR;o60 mL/min/1.73 m2), proteinuria, and hematuria. Odds ratios (ORs) and 95% confidence intervals were measured using stepwise multivariate logistic regression analyses for CKD markers based on the presence of periodontitis.
Results: Patients with periodontitis had greater unadjusted ORs for CKD markers compared to those without periodontitis, as follows: decreased eGFR, 4.07 (3.11?5.33); proteinuria, 2.12 (1.48?3.05); and hematuria, 1.25 (1.13?1.39, all Po0.001). Periodontitis was a significant predictor of decreased eGFR independent of all covariates [1.39 (1.03?1.89), P¼0.034]. However, the effect of periodontitis on decreased eGFR seemed to be affected by hypertension and diabetes mellitus. Periodontitis was not an independent predictor of proteinuria; the significance disappeared after adjusting for hypertension and diabetes mellitus. Periodontitis was significantly correlated with hematuria, leading to similar ORs regardless of the adjustment for covariates [1.29 (1.15?1.46), Po0.001].
Conclusion: This study confirms the correlation between periodontitis and CKD markers, including decreased eGFR, proteinuria, and hematuria in Korean adults.
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KEYWORD
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Glomerular filtration rate, Hematuria, Periodontal diseases, Periodontitis, Proteinuria
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